Genome-Wide Identification and Characterization of the BRD Family in Nile Tilapia (Oreochromis niloticus).

ABSTRACT: The bromodomain (BRD) proteins specifically recognize the N-acetyllysine motifs, which is a key event in the reading process of epigenetic marks. BRDs are evolutionarily highly conserved. Over recent years, BRDs attracted great interest because of their important roles in biological processes. However, the genome-wide identification of this family was not carried out in many animal groups, in particular, in teleosts. Moreover, the expression patterns were not reported for any of the members in this family, and the role of the BRD family was not extensively studied in fish reproduction. In this study, we identified 16 to 120 BRD genes in 24 representative species. BRDs expanded significantly in vertebrates. Phylogenetic analysis showed that the BRD family was divided into eight subfamilies

SUBMITTER: Xu C 

PROVIDER: S-EPMC9454494 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature