Inhibition of Autophagy Promotes the Anti-Tumor Effect of Metformin in Oral Squamous Cell Carcinoma

ABSTRACT:

Simple Summary

In this study, we found that metformin could inhibit the cell proliferation of Oral Squamous Cell Carcinoma (OSCC) by promoting apoptosis and blocking the cell cycle. Furthermore, inhibiting autophagy with hydroxychloroquine (HCQ) could enhance the anti-tumor effect of metformin in OSCC.

Abstract

Oral Squamous Cell Carcinoma (OSCC) is the most common malignant tumor in the head and neck. Due to its high malignancy and easy recurrence, the five-year survival rate is only 50–60%. Currently, commonly used chemotherapy drugs for OSCC include cisplatin, paclitaxel, and fluorouracil, which are highly cytotoxic and cause drug resistance in patients. Therefore, a safe and effective treatment strategy for OSCC is urgent. To address this issue, our study investigated

SUBMITTER: Zhao W 

PROVIDER: S-EPMC9454503 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature