High Fat Diet Multigenerationally Affects Hippocampal Neural Stem Cell Proliferation via Epigenetic Mechanisms.

ABSTRACT: Early-life metabolic stress has been demonstrated to affect brain development, persistently influence brain plasticity and to exert multigenerational effects on cognitive functions. However, the impact of an ancestor's diet on the adult neurogenesis of their descendants has not yet been investigated. Here, we studied the effects of maternal high fat diet (HFD) on hippocampal adult neurogenesis and the proliferation of neural stem and progenitor cells (NSPCs) derived from the hippocampus of both the second and the third generations of progeny (F2_HFD and F3_HFD). Maternal HFD caused a multigenerational depletion of neurogenic niche in F2_HFD and F3_HFD mice. Moreover, NSPCs derived from HFD descendants showed altered expression of genes regulating ste

SUBMITTER: Natale F 

PROVIDER: S-EPMC9454549 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature