Contributions of Circulating microRNAs for Early Detection of Lung Cancer

ABSTRACT:

Simple Summary

Blood-based cancer biomarkers are a minimally invasive means to achieve improved assessment of risk and/or earlier detection of lung cancer. Using serum samples from individuals that went on to develop lung cancer within one year following blood draw and from matched controls, we investigated 30 microRNAs for individual and combined utility to discriminate lung cancer cases from controls. We additionally assessed the contributions of top-performing microRNA candidates for improving on the performance of a previously validated four-protein marker panel for lung cancer detection. The results of this study indicate complementary performance of combining circulating microRNA and the four-protein-marker panel in assays for early detection of lung cancer.

Abstract

SUBMITTER: Vykoukal J 

PROVIDER: S-EPMC9454665 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature