Ontology highlight
ABSTRACT:
SUBMITTER: Belli C
PROVIDER: S-EPMC9454727 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
Belli Carmen C Antonarelli Gabriele G Repetto Matteo M Boscolo Bielo Luca L Crimini Edoardo E Curigliano Giuseppe G
Cancers 20220901 17
Cancers are composed of transformed cells, characterized by aberrant growth and invasiveness, in close relationship with non-transformed healthy cells and stromal tissue. The latter two comprise the so-called tumor microenvironment (TME), which plays a key role in tumorigenesis, cancer progression, metastatic seeding, and therapy resistance. In these regards, cancer-TME interactions are complex and dynamic, with malignant cells actively imposing an immune-suppressive and tumor-promoting state on ...[more]