The CaMKII/MLC1 Axis Confers Ca²⁺-Dependence to Volume-Regulated Anion Channels (VRAC) in Astrocytes.

ABSTRACT: Astrocytes, the main glial cells of the central nervous system, play a key role in brain volume control due to their intimate contacts with cerebral blood vessels and the expression of a distinctive equipment of proteins involved in solute/water transport. Among these is MLC1, a protein highly expressed in perivascular astrocytes and whose mutations cause megalencephalic leukoencephalopathy with subcortical cysts (MLC), an incurable leukodystrophy characterized by macrocephaly, chronic brain edema, cysts, myelin vacuolation, and astrocyte swelling. Although, in astrocytes, MLC1 mutations are known to affect the swelling-activated chloride currents (ICl,_swell) mediated by the volume-regulated anion channel (VRAC), and the regulatory volume decrease, MLC1's proper function is stil

SUBMITTER: Brignone MS 

PROVIDER: S-EPMC9454758 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature