A Single-Cell Survey of Cellular Heterogeneity in Human Great Saphenous Veins.

ABSTRACT:

Background

The great saphenous vein (GSV) is the most commonly used conduit for coronary arterial bypass graft. However, the status of the GSV, including metabolic dysfunction such as diabetes mellitus (DM) complication, is strongly associated with vein graft failure (VGF). To date, the molecular mechanism underlying VGF remains elusive. Detailed characterization of the cellular components and corresponding expression regulation in GSVs would be of great importance for clinical decision making to reduce VGF.

Methods

To this end, we performed single-cell RNA sequencing to delineate cellular heterogeneity in three human GSV samples.

Results

Scrutinization of cellular composition and expression revealed cell diversity in human GSVs, particularly endothelial cells (ECs).

SUBMITTER: Sun Y 

PROVIDER: S-EPMC9454806 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature