Protective effects of silver nanoparticles in isoproterenol-induced myocardial infarction in rats.

ABSTRACT:

Background

Silver nanoparticles (AgNPs) are widely used in the medical field, including cardiovascular. However, limited research has investigated the effect of AgNPs on the protection of myocardial infarction (MI).

Objectives

Isoproterenol (Iso)-induced MI and the cardiac protection offered by AgNPs were investigated in the present study. Additionally, we characterized the profile of Ag in the form of nanoparticles.

Methods

Twenty-four male Wistar rats were randomly divided into four groups as follows: normal, Iso, Iso + AgNO₃, and Iso + AgNP groups. AgNPs and silver ion (AgNO₃) were administered intraperitoneally at 2.5 mg/kg BW for 14 days. Iso induction was performed using two doses of 85 mg/kg BW given subcutaneously on days 13 and 14. Blood

SUBMITTER: Arozal W 

PROVIDER: S-EPMC9454814 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature