Genetic Mouse Models to Study Pancreatic Cancer-Induced Pain and Reduction in Well-Being.

ABSTRACT: In addition to the poor prognosis, excruciating abdominal pain is a major challenge in pancreatic cancer. Neurotropism appears to be the underlying mechanism leading to neuronal invasion. However, there is a lack of animal models suitable for translationally bridging in vitro findings with clinical trials. We characterized KPC (Kras^G12D/+; Trp53^R172H/+; P48-Cre) and KPPC (Kras^G12D/+; Trp53^R172H/R172H; P48-Cre) mice with genetically determined pancreatic ductal adenocarcinoma (PDAC) and compared them with an orthotopic pancreatic cancer mouse model, healthy littermates and human tissue. We analyzed behavioral correlates of cancer-associated pain and well-being, and studied neuronal remodeling and cytokine expression. Histologically, we found simil

SUBMITTER: Hirth M 

PROVIDER: S-EPMC9454877 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature