Endometrial Cancer Detection Using a Cervical DNA Methylation Assay (MPap) in Women with Abnormal Uterine Bleeding: A Multicenter Hospital-Based Validation Study.

ABSTRACT:

Background

We describe a DNA methylation assay, named MPap test, using cervical scraping as an alternative technique for endometrial cancer detection.

Methods

A multicenter hospital-based, two-stage validation study was conducted to validate the cancer detection performance of the MPap test. The MPap value was determined from the DNA methylation status of two genes (BHLHE22, CDO1) and combined with two other clinical variables (age, BMI). The cutoff threshold of the MPap value was established in stage 1 and validated in stage 2. A total of 592 women with abnormal uterine bleeding were enrolled from five medical centers throughout Taiwan.

Results

In stage 1, the sensitivity, specificity, and positive and negative predictive values of the MPap test for detecting

SUBMITTER: Wen KC 

PROVIDER: S-EPMC9454900 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature