Cancer Cachexia: Signaling and Transcriptional Regulation of Muscle Catabolic Genes.

ABSTRACT: Cancer cachexia (CC) is a multifactorial syndrome characterized by a significant reduction in body weight that is predominantly caused by the loss of skeletal muscle and adipose tissue. Although the ill effects of cachexia are well known, the condition has been largely overlooked, in part due to its complex etiology, heterogeneity in mediators, and the involvement of diverse signaling pathways. For a long time, inflammatory factors have been the focus when developing therapeutics for the treatment of CC. Despite promising pre-clinical results, they have not yet advanced to the clinic. Developing new therapies requires a comprehensive understanding of how deregulated signaling leads to catabolic gene expression that underlies muscle wasting. Here, we review CC-associated signaling pathways

SUBMITTER: Rao VK 

PROVIDER: S-EPMC9454911 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature