Effect of Porcine Colostral Exosomes on T Cells in the Peripheral Blood of Suckling Piglets.

ABSTRACT: Growing evidence indicates that porcine colostral exosomes may contribute to the healthy development of piglets. Here, we evaluated in vitro the effect of porcine milk-derived exosomes, in particular colostral exosomes, on T cells in the peripheral blood of suckling piglets. A total of seven sows and thirteen suckling piglets were used. Peripheral blood mononuclear cells (PBMCs) from suckling piglets were cultured with or without milk-derived exosomes (control). Using flow cytometry, the proportion of each T cell subset in cultured PBMCs was analyzed three days post-incubation. PBMCs cultured with porcine colostral exosomes had a higher proportion of CD3⁺CD4^-CD8⁺ T cells (cytotoxic T cells; Tc) than the control. However, exosomes induced no increase in the

SUBMITTER: Miura H 

PROVIDER: S-EPMC9455021 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature