Prolactin Expression in the Baboon (Papio hamadryas) Eye.

ABSTRACT: Prolactin (PRL) is a hormone expressed in lactotrophs cells of the pituitary gland in primates. Extra pituitary expression of PRL has been reported, including the eye; however, expression in the developing eye of primates is limited. The aim of the study was determining the expression of PRL and PRL receptor (PRLR) (mRNAs and proteins) in adult and fetal baboon (Papio hamadryas) ocular tissues.

Methods

We analyzed PRL and PRLR in baboon eyes tissues by immunofluorescence. The mRNAs of PRL and PRLR were detected by RT-PCR, cDNA was cloned, and sequenced. Furthermore, we performed a phylogenetic analysis to identify the evolutionary forces that underlie the divergence of PRL and PRLR primate genes.

Results

We observed the

SUBMITTER: Garza-Rodriguez ML 

PROVIDER: S-EPMC9455022 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature