Hydrogen Sulfide Improves Angiogenesis by Regulating the Transcription of pri-miR-126 in Diabetic Endothelial Cells.

ABSTRACT:

Introduction

Diabetes mellitus results in high rates of cardiovascular disease, such as microcirculation disorder of the lower limbs, with angiogenesis impairment being the main factor. The endothelium functions as a barrier between blood and the vessel wall. Vascular endothelial cell dysfunction caused by hyperglycemia is the main factor leading to angiogenesis impairment. Hydrogen sulfide (H₂S) and miR-126-3p are known for their pro-angiogenesis effects; however, little is known about how H₂S regulates miR-126-3p to promote angiogenesis under high-glucose conditions.

Objectives

The main objective of this research was to explore how H₂S regulates the miR-126-3p levels under high-glucose conditions.

Methods

We evaluated the pro-angioge

SUBMITTER: Xue W 

PROVIDER: S-EPMC9455028 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature