Immune Determinants of Viral Clearance in Hospitalised COVID-19 Patients: Reduced Circulating Naive CD4+ T Cell Counts Correspond with Delayed Viral Clearance.

ABSTRACT: Virus-specific cellular and humoral responses are major determinants for protection from critical illness after SARS-CoV-2 infection. However, the magnitude of the contribution of each of the components to viral clearance remains unclear. Here, we studied the timing of viral clearance in relation to 122 immune parameters in 102 hospitalised patients with moderate and severe COVID-19 in a longitudinal design. Delayed viral clearance was associated with more severe disease and was associated with higher levels of SARS-CoV-2-specific (neutralising) antibodies over time, increased numbers of neutrophils, monocytes, basophils, and a range of pro-inflammatory cyto-/chemokines illustrating ongoing, partially Th2 dominating, immune activation. In contrast, early viral clearance and less critical i

SUBMITTER: Zlei M 

PROVIDER: S-EPMC9455062 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature