Leishmania infection-derived extracellular vesicles drive transcription of genes involved in M2 polarization.

ABSTRACT: Although it is known that the composition of extracellular vesicles (EVs) is determined by the characteristics of the cell and its environment, the effects of intracellular infection on EV composition and functions are not well understood. We had previously shown that cultured macrophages infected with Leishmania parasites release EVs (LiEVs) containing parasite-derived molecules. In this study we show that LdVash, a molecule previously identified in LiEVs from L. donovani infected RAW264.7 macrophages, is widely distributed in the liver of L. donovani infected mice. This result shows for the first time that parasite molecules are released in EVs and distributed in infected tissues where they can be endocytosed by cells in the liver, including macrophages that signific

SUBMITTER: Emerson LE 

PROVIDER: S-EPMC9455154 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature