Ontology highlight
ABSTRACT:
SUBMITTER: El Abdellaoui-Soussi F
PROVIDER: S-EPMC9455175 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
El Abdellaoui-Soussi Fadoua F Yunes-Leites Paula S PS López-Maderuelo Dolores D García-Marqués Fernando F Vázquez Jesús J Redondo Juan Miguel JM Gómez-Del Arco Pablo P
International journal of molecular sciences 20220824 17
The sarcomere regulates striated muscle contraction. This structure is composed of several myofibril proteins, isoforms of which are encoded by genes specific to either the heart or skeletal muscle. The chromatin remodeler complex Chd4/NuRD regulates the transcriptional expression of these specific sarcomeric programs by repressing genes of the skeletal muscle sarcomere in the heart. Aberrant expression of skeletal muscle genes induced by the loss of Chd4 in the heart leads to sudden death due t ...[more]