Lead Exposure Causes Spinal Curvature during Embryonic Development in Zebrafish.

ABSTRACT: Lead (Pb) is an important raw material for modern industrial production, they enter the aquatic environment in several ways and cause serious harm to aquatic ecosystems. Lead ions (Pb²⁺) are highly toxic and can accumulate continuously in organisms. In addition to causing biological deaths, it can also cause neurological damage in vertebrates. Our experiment found that Pb²⁺ caused decreased survival, delayed hatching, decreased frequency of voluntary movements at 24 hpf, increased heart rate at 48 hpf and increased malformation rate in zebrafish embryos. Among them, the morphology of spinal malformations varied, with 0.4 mg/L Pb²⁺ causing a dorsal bending of the spine of 72 hpf zebrafish and a ventral bending in 120 hpf zebrafish. It was detected that spina

SUBMITTER: Li X 

PROVIDER: S-EPMC9455242 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature