Ontology highlight
ABSTRACT:
SUBMITTER: Malbeteau L
PROVIDER: S-EPMC9455263 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Malbeteau Lucie L Jacquemetton Julien J Languilaire Cécile C Corbo Laura L Le Romancer Muriel M Poulard Coralie C
International journal of molecular sciences 20220823 17
The progesterone receptor (PR) is a key player in major physiological and pathological responses in women, and the signaling pathways triggered following hormone binding have been extensively studied, particularly with respect to breast cancer development and progression. Interestingly, growing evidence suggests a fundamental role for PR on breast cancer cell homeostasis in hormone-depleted conditions, with hormone-free or unliganded PR (uPR) involved in the silencing of relevant genes prior to ...[more]