PRMT1, a Key Modulator of Unliganded Progesterone Receptor Signaling in Breast Cancer.

ABSTRACT: The progesterone receptor (PR) is a key player in major physiological and pathological responses in women, and the signaling pathways triggered following hormone binding have been extensively studied, particularly with respect to breast cancer development and progression. Interestingly, growing evidence suggests a fundamental role for PR on breast cancer cell homeostasis in hormone-depleted conditions, with hormone-free or unliganded PR (uPR) involved in the silencing of relevant genes prior to hormonal stimulation. We herein identify the protein arginine methyltransferase PRMT1 as a novel actor in uPR signaling. In unstimulated T47D breast cancer cells, PRMT1 interacts and functions alongside uPR and its partners to target endogenous progesterone-responsive promoters. PRMT1 helps to finel

SUBMITTER: Malbeteau L 

PROVIDER: S-EPMC9455263 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature