The Role of Blood-Derived Factors in Protection and Regeneration of Aged Tissues.

ABSTRACT: Tissue regeneration substantially relies on the functionality of tissue-resident endogenous adult stem cell populations. However, during aging, a progressive decline in organ function and regenerative capacities impedes endogenous repair processes. Especially the adult human heart is considered as an organ with generally low regenerative capacities. Interestingly, beneficial effects of systemic factors carried by young blood have been described in diverse organs including the heart, brain and skeletal muscle of the murine system. Thus, the interest in young blood or blood components as potential therapeutic agents to target age-associated malignancies led to a wide range of preclinical and clinical research. However, the translation of promising results from the murine to the human system

SUBMITTER: Hoving AL 

PROVIDER: S-EPMC9455681 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature