Curation of the AMRFinderPlus databases: applications, functionality and impact.

ABSTRACT: Antimicrobial resistance (AMR) is a significant public health threat. Low-cost whole-genome sequencing, which is often used in surveillance programmes, provides an opportunity to assess AMR gene content in these genomes using in silico approaches. A variety of bioinformatic tools have been developed to identify these genomic elements. Most of those tools rely on reference databases of nucleotide or protein sequences and collections of models and rules for analysis. While the tools are critical for the identification of AMR genes, the databases themselves also provide significant utility for researchers, for applications ranging from sequence analysis to information about AMR phenotypes. Additionally, these databases can be evaluated by domain experts and others to ensure their accur

SUBMITTER: Feldgarden M 

PROVIDER: S-EPMC9455714 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature