Fatty Acid-Binding Proteins: Their Roles in Ischemic Stroke and Potential as Drug Targets.

ABSTRACT: Stroke is among the leading causes of death and disability worldwide. However, despite long-term research yielding numerous candidate neuroprotective drugs, there remains a lack of effective neuroprotective therapies for ischemic stroke patients. Among the factors contributing to this deficiency could be that single-target therapy is insufficient in addressing the complex and extensive mechanistic basis of ischemic brain injury. In this context, lipids serve as an essential component of multiple biological processes and play important roles in the pathogenesis of numerous common neurological diseases. Moreover, in recent years, fatty acid-binding proteins (FABPs), a family of lipid chaperone proteins, have been discovered to be involved in the onset or development of several neurodegenerat

SUBMITTER: Guo Q 

PROVIDER: S-EPMC9455833 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature