The Vibrio cholerae Seventh Pandemic Islands act in tandem to defend against a circulating phage.

ABSTRACT: The current circulating pandemic El Tor biotype of Vibrio cholerae has persisted for over sixty years and is characterized by its acquisition of two unique genomic islands called the Vibrio Seventh Pandemic Islands 1 and 2 (VSP-I and VSP-II). However, the functions of most of the genes on VSP-I and VSP-II are unknown and the advantages realized by El Tor through these two islands are not clear. Recent studies have broadly implicated these two mobile genetic elements with phage defense. Still, protection against phage infection through these islands has not been observed directly in any V. cholerae El Tor biotype. Here we report the isolation of a circulating phage from a cholera patient stool sample and demonstrate that propagation of this phage in its native host is inhibited by elements

SUBMITTER: O'Hara BJ 

PROVIDER: S-EPMC9455884 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature