A recombinant rabies vaccine that prevents viral shedding in rabid common vampire bats (Desmodus rotundus).

ABSTRACT: Vampire bat transmitted rabies (VBR) is a continuing burden to public health and agricultural sectors in Latin America, despite decades-long efforts to control the disease by culling bat populations. Culling has been shown to disperse bats, leading to an increased spread of rabies. Thus, non-lethal strategies to control VBR, such as vaccination, are desired. Here, we evaluated the safety and efficacy of a viral-vectored recombinant mosaic glycoprotein rabies vaccine candidate (RCN-MoG) in vampire bats (Desmodus rotundus) of unknown history of rabies exposure captured in México and transported to the United States. Vaccination with RCN-MoG was demonstrated to be safe, even in pregnant females, as no evidence of lesions or adverse effects were observed. We detected rabies neutralizing antibo

SUBMITTER: Cardenas-Canales EM 

PROVIDER: S-EPMC9455887 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature