Ontology highlight
ABSTRACT:
SUBMITTER: Spraakman NA
PROVIDER: S-EPMC9455962 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Spraakman Nora A NA Coester Annemieke M AM Bourgonje Arno R AR Nieuwenhuijs Vincent B VB Sanders Jan-Stephan F JF Leuvenink Henri G D HGD van Goor Harry H Nieuwenhuijs-Moeke Gertrude J GJ
International journal of molecular sciences 20220829 17
During ischemia−reperfusion injury (IRI), reactive oxygen species are produced that can be scavenged by free sulfhydryl groups (R-SH, free thiols). In this study, we hypothesized that R-SH levels decrease as a consequence of renal IRI and that R-SH levels reflect post-transplant graft function. Systemic venous, arterial, renal venous, and urinary samples were collected in donors and recipients before, during, and after transplantation. R-SH was measured colorimetrically. Systemic arterial R-SH l ...[more]