Mechano-Sensing Channel PIEZO2 Enhances Invasive Phenotype in Triple-Negative Breast Cancer.

ABSTRACT:

Background

Mechanically gated PIEZO channels lead to an influx of cations, activation of additional Ca²⁺ channels, and cell depolarization. This study aimed to investigate PIEZO2's role in breast cancer.

Methods

The clinical relevance of PIEZO2 expression in breast cancer patient was analyzed in a publicly available dataset. Utilizing PIEZO2 overexpressed breast cancer cells, and in vitro and in vivo experiments were conducted.

Results

High expression of PIEZO2 was correlated with a worse survival in triple-negative breast cancer (TNBC) but not in other subtypes. Increased PEIZO2 channel function was confirmed in PIEZO2 overexpressed cells after mechanical stimulation. PIEZO2 overexpressed cells showed increa

SUBMITTER: Katsuta E 

PROVIDER: S-EPMC9455988 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature