Implication of Irisin in Different Types of Cancer: A Systematic Review and Meta-Analysis.

ABSTRACT: Cancer is a set of diseases characterized by several hallmark properties, such as increased angiogenesis, proliferation, invasion, and metastasis. The increased angiogenic activity constantly supplies the tumors with nutrients and a plethora of cytokines to ensure cell survival. Along these cytokines is a newly discovered protein, called irisin, which is released into the circulation after physical exercise. Irisin is the product of fibronectin type III domain-containing protein 5 (FNDC5) proteolytic cleavage. Recently it has been the topic of investigation in several types of cancer. In this study, we conducted a systematic review and meta-analysis to investigate its implication in different types of cancer. Our results suggest that irisin expression is decreased in cancer patients, thus

SUBMITTER: Vliora M 

PROVIDER: S-EPMC9456043 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature