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Insight into the Mammalian Aquaporin Interactome.


ABSTRACT: Aquaporins (AQPs) are a family of transmembrane water channels expressed in all living organisms. AQPs facilitate osmotically driven water flux across biological membranes and, in some cases, the movement of small molecules (such as glycerol, urea, CO2, NH3, H2O2). Protein-protein interactions play essential roles in protein regulation and function. This review provides a comprehensive overview of the current knowledge of the AQP interactomes and addresses the molecular basis and functional significance of these protein-protein interactions in health and diseases. Targeting AQP interactomes may offer new therapeutic avenues as targeting individual AQPs remains challenging despite intense efforts.

SUBMITTER: Tornroth-Horsefield S 

PROVIDER: S-EPMC9456110 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature

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Insight into the Mammalian Aquaporin Interactome.

Törnroth-Horsefield Susanna S   Chivasso Clara C   Strandberg Helin H   D'Agostino Claudia C   O'Neale Carla V T CVT   Schey Kevin L KL   Delporte Christine C  

International journal of molecular sciences 20220825 17


Aquaporins (AQPs) are a family of transmembrane water channels expressed in all living organisms. AQPs facilitate osmotically driven water flux across biological membranes and, in some cases, the movement of small molecules (such as glycerol, urea, CO<sub>2</sub>, NH<sub>3</sub>, H<sub>2</sub>O<sub>2</sub>). Protein-protein interactions play essential roles in protein regulation and function. This review provides a comprehensive overview of the current knowledge of the AQP interactomes and addre  ...[more]

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