A Lupin (Lupinusangustifolius) Protein Hydrolysate Exerts Anxiolytic-Like Effects in Western Diet-Fed ApoE^-/- Mice.

ABSTRACT: Anxiety is the most prevalent psychiatric disorder worldwide, causing a substantial economic burden due to the associated healthcare costs. Given that commercial anxiolytic treatments may cause important side effects and have medical restrictions for prescription and high costs, the search for new natural and safer treatments is gaining attention. Since lupin protein hydrolysate (LPH) has been shown to be safe and exert anti-inflammatory and antioxidant effects, key risk factors for the anxiety process and memory impairment, we evaluated in this study the potential effects of LPH on anxiety and spatial memory in a Western diet (WD)-induced anxiety model in ApoE^-/- mice. We showed that 20.86% of the 278 identified LPH peptides have biological activity related to anxiolytic/analge

SUBMITTER: Santos-Sanchez G 

PROVIDER: S-EPMC9456304 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature