Host Cell Signatures of the Envelopment Site within Beta-Herpes Virions.

ABSTRACT: Beta-herpesvirus infection completely reorganizes the membrane system of the cell. This system is maintained by the spatiotemporal arrangement of more than 3000 cellular proteins that continuously adapt the configuration of membrane organelles according to cellular needs. Beta-herpesvirus infection establishes a new configuration known as the assembly compartment (AC). The AC membranes are loaded with virus-encoded proteins during the long replication cycle and used for the final envelopment of the newly formed capsids to form infectious virions. The identity of the envelopment membranes is still largely unknown. Electron microscopy and immunofluorescence studies suggest that the envelopment occurs as a membrane wrapping around the capsids, similar to the growth of phagophores, in the area

SUBMITTER: Mahmutefendic Lucin H 

PROVIDER: S-EPMC9456339 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature