Phylogenetic and Expression Analysis of Fos Transcription Factors in Zebrafish.

ABSTRACT: Members of the FOS protein family regulate gene expression responses to a multitude of extracellular signals and are dysregulated in several pathological states. Whilst mouse genetic models have provided key insights into the tissue-specific functions of these proteins in vivo, little is known about their roles during early vertebrate embryonic development. This study examined the potential of using zebrafish as a model for such studies and, more broadly, for investigating the mechanisms regulating the functions of Fos proteins in vivo. Through phylogenetic and sequence analysis, we identified six zebrafish FOS orthologues, fosaa, fosab, fosb, fosl1a, fosl1b, and fosl2, which show high conservation in key regulatory domains and post-translational modification sites com

SUBMITTER: Kubra K 

PROVIDER: S-EPMC9456341 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature