PTPRO represses colorectal cancer tumorigenesis and progression by reprogramming fatty acid metabolism.

ABSTRACT:

Background

Abnormal expression of protein tyrosine phosphatases (PTPs) has been reported to be a crucial cause of cancer. As a member of PTPs, protein tyrosine phosphatase receptor type O (PTPRO) has been revealed to play tumor suppressive roles in several cancers, while its roles in colorectal cancer (CRC) remains to be elucidated. Hence, we aimed to explore the roles and mechanisms of PTPRO in CRC initiation and progression.

Methods

The influences of PTPRO on the growth and liver metastasis of CRC cells and the expression patterns of different lipid metabolism enzymes were evaluated in vitro and in vivo. Molecular and biological experiments were conducted to uncover the underpinning mechanisms of dysregulated de novo lipogenesis and fatty acid β-oxidation.

Results

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SUBMITTER: Dai W 

PROVIDER: S-EPMC9456702 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature