ER-resident STIM1/2 couples Ca²⁺ entry by NMDA receptors to pannexin-1 activation.

ABSTRACT: Pannexin-1 (Panx1) is a large-pore ion and solute permeable channel highly expressed in the nervous system, where it subserves diverse processes, including neurite outgrowth, dendritic spine formation, and N-methyl D-aspartate (NMDA) receptor (NMDAR)-dependent plasticity. Moreover, Panx1 dysregulation contributes to neurological disorders, including neuropathic pain, epilepsy, and excitotoxicity. Despite progress in understanding physiological and pathological functions of Panx1, the mechanisms that regulate its activity, including its ion and solute permeability, remain poorly understood. In this study, we identify endoplasmic reticulum (ER)-resident stromal interaction molecules (STIM1/2), which are Ca²⁺ sensors that communicate events within the ER to plasma membrane channels

SUBMITTER: Patil CS 

PROVIDER: S-EPMC9456761 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature