Plasma Lipidomics Approach in Early and Specific Alzheimer's Disease Diagnosis.

ABSTRACT:

Background

The brain is rich in lipid content, so a physiopathological pathway in Alzheimer's disease (AD) could be related to lipid metabolism impairment. The study of lipid profiles in plasma samples could help in the identification of early AD changes and new potential biomarkers.

Methods

An untargeted lipidomic analysis was carried out in plasma samples from preclinical AD (n = 11), mild cognitive impairment-AD (MCI-AD) (n = 31), and healthy (n = 20) participants. Variables were identified by means of two complementary methods, and lipid families' profiles were studied. Then, a targeted analysis was carried out for some identified lipids.

Results

Statistically significant differences were obtained for the diglycerol (DG), lysophosphatidylethan

SUBMITTER: Pena-Bautista C 

PROVIDER: S-EPMC9457360 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature