Frequency of bystander exposure to antibiotics for enteropathogenic bacteria among young children in low-resource settings.

ABSTRACT: Children in low-resource settings carry enteric pathogens asymptomatically and are frequently treated with antibiotics, resulting in opportunities for pathogens to be exposed to antibiotics when not the target of treatment (i.e., bystander exposure). We quantified the frequency of bystander antibiotic exposures for enteric pathogens and estimated associations with resistance among children in eight low-resource settings. We analyzed 15,697 antibiotic courses from 1,715 children aged 0 to 2 y from the MAL-ED birth cohort. We calculated the incidence of bystander exposures and attributed exposures to respiratory and diarrheal illnesses. We associated bystander exposure with phenotypic susceptibility of E. coli isolates in the 30 d following exposure and at the level of the study site. There

SUBMITTER: Rogawski McQuade ET 

PROVIDER: S-EPMC9457395 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature