Construction of Benzenesulfonamide Derivatives via Copper and Visible Light-induced Azides and S(O)2-H Coupling.
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ABSTRACT: We here have developed an S(O)2-N coupling between phenylsulfinic acid derivatives and aryl azides by dual copper and visible light catalysis. In this efficient and mild pathway, the reaction produces sulfonamide compounds under redox-neutral condition, which is mechanistically different from the nitrogen nucleophilic substitution reactions. Significantly, this transformation intends to utilize the property of visible light-induced azides to generate triplet nitrene and followed coupling with sulfonyl radicals in situ to achieve structurally diverse benzenesulfinamides in good yields.
SUBMITTER: Liang Z
PROVIDER: S-EPMC9457716 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
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