Virtual Screening in the Identification of Sirtuins' Activity Modulators.

ABSTRACT: Sirtuins are NAD⁺-dependent deac(et)ylases with different subcellular localization. The sirtuins' family is composed of seven members, named SIRT-1 to SIRT-7. Their substrates include histones and also an increasing number of different proteins. Sirtuins regulate a wide range of different processes, ranging from transcription to metabolism to genome stability. Thus, their dysregulation has been related to the pathogenesis of different diseases. In this review, we discussed the pharmacological approaches based on sirtuins' modulators (both inhibitors and activators) that have been attempted in in vitro and/or in in vivo experimental settings, to highlight the therapeutic potential of targeting one/more specific sirtuin isoform(s) in cancer, neurodegenerative disorders and type 2

SUBMITTER: Abbotto E 

PROVIDER: S-EPMC9457788 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature