Indomethacin: The Interplay between Structural Relaxation, Viscous Flow and Crystal Growth.

ABSTRACT: Non-isothermal differential scanning calorimetry (DSC) was used to study the influences of particle size (d_aver) and heating rate (q⁺) on the structural relaxation, crystal growth and decomposition kinetics of amorphous indomethacin. The structural relaxation and decomposition processes exhibited d_aver-independent kinetics, with the q⁺ dependences based on the apparent activation energies of 342 and 106 kJ·mol^-1, respectively. The DSC-measured crystal growth kinetics played a dominant role in the nucleation throughout the total macroscopic amorphous-to-crystalline transformation: the change from the zero-order to the autocatalytic mechanism with increasing q⁺, the significant alteration of kinetics, with the storage below th

SUBMITTER: Svoboda R 

PROVIDER: S-EPMC9458118 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature