Association between Circulating Levels of 25-Hydroxyvitamin D₃ and Matrix Metalloproteinase-10 (MMP-10) in Patients with Type 2 Diabetes.

ABSTRACT:

Background

Matrix metalloproteinase-10 (MMP-10) levels increase progressively starting from early diabetic kidney disease (DKD) stages. Vitamin D₃ (vitD₃) deficit is associated with a higher risk of diabetic microangiopathy. Reduced MMP-10 expression has been observed after exposure to vitD₃.

Aim

to assess how vitD₃ status is related to MMP-10 levels in patients with Type 2 diabetes (T2D).

Methods

256 patients with T2D were included in this cross-sectional study. Demographic, clinical and serum MMP-10 and 25-hydroxyvitamin D₃ (25(OH)D₃) levels were collected from each patient. The association between MMP-10 and (25(OH)D₃) levels was assessed using a correlation analysis and fitting a multivar

SUBMITTER: Abasheva D 

PROVIDER: S-EPMC9458174 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature