Comparison of Transcriptomic Signatures between Monkeypox-Infected Monkey and Human Cell Lines.

ABSTRACT: Monkeypox virus (MPV) is a smallpox-like virus belonging to the genus Orthopoxvirus of the family Poxviridae. Unlike smallpox with no animal reservoir identified and patients suffering from milder symptoms with less mortality, several animals were confirmed to serve as natural hosts of MPV. The reemergence of a recently reported monkeypox epidemic outbreak in nonendemic countries has raised concerns about a global outburst. Since the underlying mechanism of animal-to-human transmission remains largely unknown, comprehensive analyses to discover principal differences in gene signatures during disease progression have become ever more critical. In this study, two MPV-infected in vitro models, including human immortal epithelial cancer (HeLa) cells and rhesus monkey (Macaca m

SUBMITTER: Xuan DTM 

PROVIDER: S-EPMC9458371 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature