Ontology highlight
ABSTRACT:
SUBMITTER: Hao H
PROVIDER: S-EPMC9458434 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
Hao Haojie H Liu Weichi W Miao Yuanjiu Y Ma Li L Yu Baocheng B Liu Lishi L Yang Chunjie C Zhang Kui K Chen Zhen Z Yang Jingwen J Zheng Zhenhua Z Zhang Bo B Deng Fei F Gong Peng P Yuan Jianhui J Hu Zhangli Z Guan Wuxiang W
Nucleic acids research 20220901 16
Chemical modifications are important for RNA function and metabolism. N4-acetylcytidine (ac4C) is critical for the translation and stability of mRNA. Although ac4C is found in RNA viruses, the detailed mechanisms through which ac4C affects viral replication are unclear. Here, we reported that the 5' untranslated region of the enterovirus 71 (EV71) genome was ac4C modified by the host acetyltransferase NAT10. Inhibition of NAT10 and mutation of the ac4C sites within the internal ribosomal entry s ...[more]