Prp43/DHX15 exemplify RNA helicase multifunctionality in the gene expression network.

ABSTRACT: Dynamic regulation of RNA folding and structure is critical for the biogenesis and function of RNAs and ribonucleoprotein (RNP) complexes. Through their nucleotide triphosphate-dependent remodelling functions, RNA helicases are key modulators of RNA/RNP structure. While some RNA helicases are dedicated to a specific target RNA, others are multifunctional and engage numerous substrate RNAs in different aspects of RNA metabolism. The discovery of such multitasking RNA helicases raises the intriguing question of how these enzymes can act on diverse RNAs but also maintain specificity for their particular targets within the RNA-dense cellular environment. Furthermore, the identification of RNA helicases that sit at the nexus between different aspects of RNA metabolism raises the possibility tha

SUBMITTER: Bohnsack KE 

PROVIDER: S-EPMC9458436 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature