The number of brain metastases predicts the survival of non-small cell lung cancer patients with EGFR mutation status.

ABSTRACT:

Background

Lung cancer is the common cause of cancer-related deaths throughout the world, and brain is a frequent metastatic site of lung cancer.

Aim

This research sought to evaluate the impact of the number of brain metastases in prognosticating non-small cell lung cancer (NSCLC) patients accounting to the role of epidermal growth factor receptor (EGFR) mutations.

Methods and results

NSCLC patients with brain metastases diagnosed/treated in West China Hospital, Sichuan University between 2009 and 2017 were identified retrospectively. Kaplan-Meier approach was adopted to estimate OS. And we performed univariate and multivariate Cox proportional hazards regression analyses of characteristics related to overall survival (OS) in both EGFR-mutated and wild-type cohorts. I

SUBMITTER: Shao J 

PROVIDER: S-EPMC9458511 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature