[FNDC1 is highly expressed in lung adenocarcinoma and closely related with poor prognosis].

ABSTRACT:

Objective

To explore the expression of fibronectin type Ⅲ domain containing 1(FNDC1) protein in lung adenocarcinoma and its prognostic significance.

Methods

The expression of FNDC1 in lung adenocarcinoma was predicted by analysis of data from GEO database and GEPIA, and the results were verified by immunohistochemical staining in 92 pairs of clinical specimens of lung adenocarcinoma and adjacent tissues.We further analyzed the correlation of FNDC1 expression with the clinicopathological features of the patients, and evaluated its prognostic value using Cox survival analysis.

Results

Analysis of the data form GEO database and GEPIA showed a significantly higher expression level of FNDC1 in lung adenocarcinoma than in matched normal tissues (P < 0.05).Kaplan-Meie

SUBMITTER: Hong H 

PROVIDER: S-EPMC9458525 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature