Analysis of time-dependent changes in the FIB4 index in patients with obesity receiving weight reduction therapy.

ABSTRACT: Weight reduction therapy represents a fundamental strategy to prevent nonalcoholic fatty liver disease (NAFLD) in patients with obesity, which may result in liver fibrosis. Histological findings previously demonstrated that weight reduction therapy attenuated NAFLD. The FIB4 index is widely used to assess the status of NAFLD. The present study investigated whether the FIB4 index improved during weight reduction therapy. We used cohort data of the Japan Obesity and Metabolic syndrome Study and examined the correlation between body weight (BW) loss (BW loss) and changes in the FIB4 index (ΔFIB4 index) in patients who successfully reduced their BW by more than 5% from baseline BW after 3, 6, and 12 months (M) of weight reduction therapy. A negative correlation (r = -0.342, p = 0.029) was obse

SUBMITTER: Kawai S 

PROVIDER: S-EPMC9458712 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature