Changes in dynamic transitions between integrated and segregated states underlie visual hallucinations in Parkinson's disease.

ABSTRACT: Hallucinations are a core feature of psychosis and common in Parkinson's. Their transient, unexpected nature suggests a change in dynamic brain states, but underlying causes are unknown. Here, we examine temporal dynamics and underlying structural connectivity in Parkinson's-hallucinations using a combination of functional and structural MRI, network control theory, neurotransmitter density and genetic analyses. We show that Parkinson's-hallucinators spent more time in a predominantly Segregated functional state with fewer between-state transitions. The transition from integrated-to-segregated state had lower energy cost in Parkinson's-hallucinators; and was therefore potentially preferable. The regional energy needed for this transition was correlated with regional neurotransmitter densit

SUBMITTER: Zarkali A 

PROVIDER: S-EPMC9458713 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature