Translational potential of hiPSCs in predictive modeling of heart development and disease.

ABSTRACT: Congenital heart disease (CHD) represents a major class of birth defects worldwide and is associated with cardiac malformations that often require surgical intervention immediately after birth. Despite the intense efforts from multicentric genome/exome sequencing studies that have identified several genetic variants, the etiology of CHD remains diverse and often unknown. Genetically modified animal models with candidate gene deficiencies continue to provide novel molecular insights that are responsible for fetal cardiac development. However, the past decade has seen remarkable advances in the field of human induced pluripotent stem cell (hiPSC)-based disease modeling approaches to better understand the development of CHD and discover novel preventative therapies. The iPSCs are derived from

SUBMITTER: Mansfield C 

PROVIDER: S-EPMC9458775 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature