Clinical validation of a population-based input function for 20-min dynamic whole-body ¹⁸F-FDG multiparametric PET imaging.

ABSTRACT:

Purpose

Contemporary PET/CT scanners can use 70-min dynamic whole-body (D-WB) PET to generate more quantitative information about FDG uptake than just the SUV by generating parametric images of FDG metabolic rate (MR_FDG). The analysis requires the late (50-70 min) D-WB tissue data combined with the full (0-70 min) arterial input function (AIF). Our aim was to assess whether the use of a scaled population-based input function (sPBIF) obviates the need for the early D-WB PET acquisition and allows for a clinically feasible 20-min D-WB PET examination.

Methods

A PBIF was calculated based on AIFs from 20 patients that were D-WB PET scanned for 120 min with simultaneous arterial blood sampling. MR_FDG imaging using PBIF requires that the area under the curve

SUBMITTER: Dias AH 

PROVIDER: S-EPMC9458803 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature