Integrated analysis of the M2 macrophage-related signature associated with prognosis in ovarian cancer.

ABSTRACT:

Background

M2 macrophages play an important role in cancer development. However, the underlying biological fator affecting M2 macrophages infiltration in ovarian cancer (OV) has not been elucidated.

Methods

R software v 4.0.0 was used for all the analysis. The expression profile and clinical information of OV patients enrolled in this study were all downloaded from The Cancer Genome Atlas and Gene Expression Omnibus databases.

Results

The CIBERSORT algorithm was used to quantify the M2 macrophage infiltration in OV tissue, which was found a risk factor for patients survival. Based on the limma package, a total of 196 DEGs were identified between OV patients with high and low M2 macrophage infiltration, which were defined as M2 macrophages related genes. Finally, the g

SUBMITTER: Peng C 

PROVIDER: S-EPMC9458878 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature