Mechanisms governing the accessibility of DNA damage proteins to constitutive heterochromatin.

ABSTRACT: Chromatin is thought to regulate the accessibility of the underlying DNA sequence to machinery that transcribes and repairs the DNA. Heterochromatin is chromatin that maintains a sufficiently high density of DNA packing to be visible by light microscopy throughout the cell cycle and is thought to be most restrictive to transcription. Several studies have suggested that larger proteins and protein complexes are attenuated in their access to heterochromatin. In addition, heterochromatin domains may be associated with phase separated liquid condensates adding further complexity to the regulation of protein concentration within chromocenters. This provides a solvent environment distinct from the nucleoplasm, and proteins that are not size restricted in accessing this liquid environment may par

SUBMITTER: Roemer A 

PROVIDER: S-EPMC9458887 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature